Multiple-drug weekly chemotherapy versus standard combination regimen in small-cell lung cancer: a phase III randomized study conducted by the European Lung Cancer Working Party.
作者： J P Sculier , M Paesmans , G Bureau , G Dabouis , P Libert
DOI: 10.1200/JCO.1993.11.10.1858
关键词: Regimen 、 Surgery 、 Vindesine 、 Gastroenterology 、 Etoposide 、 Vincristine 、 Vinblastine 、 Medicine 、 Lung cancer 、 Internal medicine 、 Cyclophosphamide 、 Chemotherapy
摘要: PURPOSEA randomized trial was conducted in patients with small-cell lung cancer (SCLC) to determine if survival can be improved by a weekly chemotherapy regimen combining various drugs.PATIENTS AND METHODSTwo hundred twenty-three were receive either six courses of multiple-drug combination (MDC) (Adriamycin [ADR; doxorubicin; Farmitalia Carlo Erba, Milan, Italy] 25 mg/m2 intravenously [i.v.] on day 1; etoposide [VP16] 120 i.v. cyclophosphamide [CPA] 500 cisplatin 60 8; vindesine [VDS] 3 vincristine [VCR] 2 mg 15; methotrexate [MTX] 100 15), or standard (SC) (ADR 50 CPA 1 g/m2 VP16 80 days 3).RESULTSIn 98 MDC-treated and 101 SC-treated assessable patients, we observed 69% 62% objective responses rates, respectively. There no significant difference survival, median durations and...
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