Unusual Presentation of an Adenocarcinoma of the Lung Metastasizing to the Mandible, Including Molecular Analysis and a Review of the Literature.

作者: Sibel Elif Gultekin , Burcu Senguven , Ipek Isik Gonul , Begum Okur , Reinhard Buettner

DOI: 10.1016/J.JOMS.2016.06.004

关键词:

摘要: Lung cancer is the most frequent cause of cancer-related death worldwide. Metastases non-small cell lung carcinoma to oral and maxillofacial region are rare. Thus, diagnosis a metastatic lesion in cavity challenging clinician pathologist. This report presents case 72-year-old man with adenocarcinoma located posterior mandibular region. Next-generation sequencing analysis showed no important mutations relevant genes except TP53 tumor suppressor gene.

参考文章(40)
Daniel Morgensztern, Ramaswamy Govindan, Siddhartha Devarakonda, Clinical applications of The Cancer Genome Atlas project (TCGA) for squamous cell lung carcinoma. Oncology. ,vol. 27, pp. 899- 906 ,(2013)
Eduardo Hochulli-Vieira, Marisa Aparecida Cabrini Gabrielli, Mario Francisco Real Gabrielli, Valfrido Antonio Pereira-Filho, Pablo Agustin Vargas, Jorge Haddad, Marcelo Donizetti Chaves, Mandible metastasis as the first sign from primary adenocarcinoma of the lung. General dentistry. ,vol. 55, pp. 224- 227 ,(2007)
, A genomics-based classification of human lung tumors Science Translational Medicine. ,vol. 5, pp. 1- 28 ,(2013) , 10.1126/SCITRANSLMED.3006802
Panagiota Economopoulou, Giannis Mountzios, Nicholas Pavlidis, George Pentheroudakis, Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer. Cancer Treatment Reviews. ,vol. 41, pp. 598- 604 ,(2015) , 10.1016/J.CTRV.2015.05.010
Nisha J. D'Silva, Don-John Summerlin, Kitrina G. Cordell, Rafik A. Abdelsayed, Charles E. Tomich, Carl T. Hanks, Dalbert Fear, Samuel Meyrowitz, Metastatic tumors in the jaws: A retrospective study of 114 cases Journal of the American Dental Association. ,vol. 137, pp. 1667- 1672 ,(2006) , 10.14219/JADA.ARCHIVE.2006.0112
Michael Kloth, Reinhard Buettner, Changing Histopathological Diagnostics by Genome-Based Tumor Classification Genes. ,vol. 5, pp. 444- 459 ,(2014) , 10.3390/GENES5020444
Su-Jin Shin, Jong-Lyel Roh, Seung-Ho Choi, Soon Yuhl Nam, Sang Yoon Kim, Sung Bae Kim, Sang-wook Lee, Kyung-Ja Cho, Metastatic carcinomas to the oral cavity and oropharynx. Korean Journal of Pathology. ,vol. 46, pp. 266- 271 ,(2012) , 10.4132/KOREANJPATHOL.2012.46.3.266
AhmetFerhat Misir, Ugur Mercan, Ömer Günhan, Metastasis of lung adenocarcinoma to the mandible: Report of a case Journal of Oral and Maxillofacial Pathology. ,vol. 17, pp. 253- 256 ,(2013) , 10.4103/0973-029X.119745
Alessandro Villa, Umberto Mariani, Francesco Villa, Oral metastasis of lung cancer. A challenge for the clinician Oral and Maxillofacial Surgery. ,vol. 16, pp. 133- 135 ,(2012) , 10.1007/S10006-011-0273-X
Rozet Tatlidil, M. Murat Gözübüyük, Mucinous Adenocarcinoma of Lung Presenting as Oral Metastases: A Case Report and Literature Review Journal of Endodontics. ,vol. 37, pp. 110- 113 ,(2011) , 10.1016/J.JOEN.2010.09.008