Cancer of Unknown Primary origin in the genomic era: Elucidating the dark box of cancer.

摘要: Cancer of Unknown Primary (CUP) comprises a heterogeneous disease group with diagnosis metastatic malignancy in the absence an identifiable primary site after diagnostic work up. CUP may either resemble specific tumor sharing common clinicopathological characteristics and prognosis, or present as distinct entity undifferentiated pathological features, usually bearing dismal prognosis. Diagnosis management have traditionally been based on therapeutic strategies mainly empirical. In last decade, advent massive gene sequencing advances genomic technologies shed light landscape CUP. Several panel tests are currently commercially available used effort to correlate those known tumor, guiding thus management. Nevertheless, these efforts hampered by rarity inability validate results such due paucity randomized clinical trials. current work, we provide overview emphasis impact genome tumors. We also discuss potential implications genomics for future treatment address challenges implementation routine practice.