Genome-wide enhancer maps link risk variants to disease genes.

作者: Nir Hacohen , Nir Hacohen , Jacob C. Ulirsch , Jacob C. Ulirsch , Jesse M. Engreitz

DOI: 10.1038/S41586-021-03446-X

关键词:

摘要: … –gene maps for 131 biological samples (biosamples) and apply these maps to analyse fine-mapped genetic … In brief, we counted gRNAs in each bin using Bowtie 50 to map reads to a …

参考文章(79)
D. K. Male, G. Pryce, C. C. W. Hughes, Antigen presentation in brain: MHC induction on brain endothelium and astrocytes compared. Immunology. ,vol. 60, pp. 453- 459 ,(1987)
S Liu, J. Z., van Sommeren, S., Huang, H., Ng, S. C., Alberts, R., Takahashi, A., ... & Abedian, Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations Nature Genetics. ,vol. 47, pp. 979- 986 ,(2015) , 10.1038/NG.3359
Jason D. Buenrostro, Beijing Wu, Howard Y. Chang, William J. Greenleaf, ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide Current protocols in molecular biology. ,vol. 109, ,(2015) , 10.1002/0471142727.MB2129S109
Hilary K Finucane, Brendan Bulik-Sullivan, Alexander Gusev, Gosia Trynka, Yakir Reshef, Po-Ru Loh, Verneri Anttila, Han Xu, Chongzhi Zang, Kyle Farh, Stephan Ripke, Felix R Day, ReproGen Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, Raci Consortium, Shaun Purcell, Eli Stahl, Sara Lindstrom, John RB Perry, Yukinori Okada, Soumya Raychaudhuri, Mark J Daly, Nick Patterson, Benjamin M Neale, Alkes L Price, None, Partitioning heritability by functional annotation using genome-wide association summary statistics Nature Genetics. ,vol. 47, pp. 1228- 1235 ,(2015) , 10.1038/NG.3404
Robert E Thurman, Eric Rynes, Richard Humbert, Jeff Vierstra, Matthew T Maurano, Eric Haugen, Nathan C Sheffield, Andrew B Stergachis, Hao Wang, Benjamin Vernot, Kavita Garg, Sam John, Richard Sandstrom, Daniel Bates, Lisa Boatman, Theresa K Canfield, Morgan Diegel, Douglas Dunn, Abigail K Ebersol, Tristan Frum, Erika Giste, Audra K Johnson, Ericka M Johnson, Tanya Kutyavin, Bryan Lajoie, Bum-Kyu Lee, Kristen Lee, Darin London, Dimitra Lotakis, Shane Neph, Fidencio Neri, Eric D Nguyen, Hongzhu Qu, Alex P Reynolds, Vaughn Roach, Alexias Safi, Minerva E Sanchez, Amartya Sanyal, Anthony Shafer, Jeremy M Simon, Lingyun Song, Shinny Vong, Molly Weaver, Yongqi Yan, Zhancheng Zhang, Zhuzhu Zhang, Boris Lenhard, Muneesh Tewari, Michael O Dorschner, R Scott Hansen, Patrick A Navas, George Stamatoyannopoulos, Vishwanath R Iyer, Jason D Lieb, Shamil R Sunyaev, Joshua M Akey, Peter J Sabo, Rajinder Kaul, Terrence S Furey, Job Dekker, Gregory E Crawford, John A Stamatoyannopoulos, None, The accessible chromatin landscape of the human genome Nature. ,vol. 489, pp. 75- 82 ,(2012) , 10.1038/NATURE11232
John W. Elrod, Jeffery D. Molkentin, Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore Japanese Circulation Journal-english Edition. ,vol. 77, pp. 1111- 1122 ,(2013) , 10.1253/CIRCJ.CJ-13-0321
Suhas SP Rao, Miriam H Huntley, Neva C Durand, Elena K Stamenova, Ivan D Bochkov, James T Robinson, Adrian L Sanborn, Ido Machol, Arina D Omer, Eric S Lander, Erez Lieberman Aiden, None, A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping Cell. ,vol. 159, pp. 1665- 1680 ,(2014) , 10.1016/J.CELL.2014.11.021
A. Liberzon, A. Subramanian, R. Pinchback, H. Thorvaldsdottir, P. Tamayo, J. P. Mesirov, Molecular signatures database (MSigDB) 3.0 Bioinformatics. ,vol. 27, pp. 1739- 1740 ,(2011) , 10.1093/BIOINFORMATICS/BTR260
Robin Andersson, Claudia Gebhard, Irene Miguel-Escalada, Ilka Hoof, Jette Bornholdt, Mette Boyd, Yun Chen, Xiaobei Zhao, Christian Schmidl, Takahiro Suzuki, Evgenia Ntini, Erik Arner, Eivind Valen, Kang Li, Lucia Schwarzfischer, Dagmar Glatz, Johanna Raithel, Berit Lilje, Nicolas Rapin, Frederik Otzen Bagger, Mette Jørgensen, Peter Refsing Andersen, Nicolas Bertin, Owen Rackham, A Maxwell Burroughs, J Kenneth Baillie, Yuri Ishizu, Yuri Shimizu, Erina Furuhata, Shiori Maeda, Yutaka Negishi, Christopher J Mungall, Terrence F Meehan, Timo Lassmann, Masayoshi Itoh, Hideya Kawaji, Naoto Kondo, Jun Kawai, Andreas Lennartsson, Carsten O Daub, Peter Heutink, David A Hume, Torben Heick Jensen, Harukazu Suzuki, Yoshihide Hayashizaki, Ferenc Müller, Fantom Consortium, Alistair RR Forrest, Piero Carninci, Michael Rehli, Albin Sandelin, None, An atlas of active enhancers across human cell types and tissues Nature. ,vol. 507, pp. 455- 461 ,(2014) , 10.1038/NATURE12787