Effect of urinary trypsin inhibitor on preterm labor with high granulocyte elastase concentration in cervical secretions.
作者： Masako Hayashi , Atsuko Oya , Hidehiko Miyake , Akihito Nakai , Toshiyuki Takeshita
DOI: 10.1272/JNMS.77.80
关键词:
摘要: Aims: To explore whether intravaginal treatment with urinary trypsin inhibitor (UTI) prevents preterm delivery in patients labor increased levels of granulocyte elastase cervical secretions. Methods: The subjects were secretions from 16 to 33 weeks gestation. Maternal and neonatal outcomes compared between receiving UTI (UTI group; n=33) those not (control n=40). Results: In UTI, the mean gestational age at was greater than that control group (37.8 vs. 35.6 weeks, p=0.003), rates premature before 34 37 gestation lower (3% 20%, p=0.028; 18% 47%, p=0.008, respectively). percentage neonates weighing more 2,500 g significantly higher group, no less 1,500 g. hospitalization rate (9% 42%, p=0.001). Conclusion: a high concentration secretions, reduced risk improved outcomes.
sci-hub.st 参考文章(21)
J D Iams, M B Landon, J Paraskos, J N Teteris, F F Johnson, Cervical sonography in preterm labor. Obstetrics & Gynecology. ,vol. 84, pp. 40- 46 ,(1994)
K. von Maillot, H.W. Stuhlsatz, V. Mohanaradhakrishnan, H. Greiling, Changes in the glycosaminoglycans distribution pattern in the human uterine cervix during pregnancy and labor. American Journal of Obstetrics and Gynecology. ,vol. 135, pp. 503- 506 ,(1979) , 10.1016/0002-9378(79)90440-X
Adriana Rivero-Marcotegui, Carlos Larrañaga-Azcárate, Rafael Ceres-Ruiz, Sergio García-Merlo, Polymorphonuclear Elastase and Interleukin-6 in Amniotic Fluid in Preterm Labor Clinical Chemistry. ,vol. 43, pp. 857- 859 ,(1997) , 10.1093/CLINCHEM/43.5.857
RF Lamont, B Dragovic, A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: the PREMET Study. British Journal of Obstetrics and Gynaecology. ,vol. 113, pp. 851- 852 ,(2006) , 10.1111/J.1471-0528.2006.00958.X
Gabor Huszar, Frederick Naftolin, The myometrium and uterine cervix in normal and preterm labor The New England Journal of Medicine. ,vol. 311, pp. 571- 581 ,(1984) , 10.1056/NEJM198408303110905
A. Fournié, Qu'est-ce qu'une « vraie » menace d'accouchement prématuré ?: Gynécol Obstét Fertil 30 (2002) 559–561 Gynecologie Obstetrique & Fertilite. ,vol. 31, pp. 101- ,(2003) , 10.1016/S1297-9589(02)00020-6
N KAGA, Y KATSUKI, Y FUTAMURA, M OBATA, Y SHIBUTANI, Role of urinary trypsin inhibitor in the maintenance of pregnancy in mice Obstetrics & Gynecology. ,vol. 88, pp. 872- 882 ,(1996) , 10.1016/0029-7844(96)00268-2
Guy M. Harbert, Efforts to reduce low birth weight and preterm births: A statewide analysis (Virginia) American Journal of Obstetrics and Gynecology. ,vol. 171, pp. 329- 340 ,(1994) , 10.1016/S0002-9378(94)70031-1
E. Wojtecka-Łukasik, J. Kaczanowska, Z. Tomczak, I. Sopata, M. Kopeć, Effects of neutral proteases from human leukocytes on plasma fibronectin. Thrombosis Research. ,vol. 33, pp. 471- 476 ,(1984) , 10.1016/0049-3848(84)90012-4
Michael J. Pugia, John A. Lott, Pathophysiology and diagnostic value of urinary trypsin inhibitors. Clinical Chemistry and Laboratory Medicine. ,vol. 43, pp. 1- 16 ,(2005) , 10.1515/CCLM.2005.001