The dual response of protein kinase Fyn to neural trauma: early induction in neurons and delayed induction in reactive astrocytes.

摘要: In the developing central nervous system, a src-related protein-tyrosine kinase fyn participates in myelination process, neuronal growth, and cytoskeletal organization. adults, has been implicated learning memory formation. To test if expression is modulated by activity, we performed quantitative situ hybridization (ISH) using brain sections of adult rats that had undergone either kainic acid (KA)-induced seizures or deafferentation (entorhinal cortex lesion, ECL). KA model, few hours after seizure activities, mRNA was elevated dentate gyrus (DG) (+45%), cerebral layer III (+35%), piriform (+25%). Conversely, consistently decreased hippocampal neurons transection major axonal inputs from entorhinal cortex. Although allegedly limited to oligodendrocytes, provide this study first evidence highly expressed astrocytes involved reactive gliosis. occurrence fyn-overexpressing increased with progress damage CA1 CA3 regions hippocampus. contrast, were not observed granular cell (DG), where damaged. Likewise, ECL most drastic change took place at near stab wound sites, levels doubled 4-10 d lesion. Collectively, our data suggest (i) an early induction linked (ii) delayed damaged cells may play novel signaling roles during glial response.