Stimulation of Myelin Basic Protein Gene Transcription by Fyn Tyrosine Kinase for Myelination

摘要: Myelin is synthesized about the time of birth. The Src-family tyrosine kinase Fyn involved in initial events myelination. present myelin-forming cells and activated through stimulation cell surface receptors such as large myelin-associated glycoprotein (L-MAG). Here we show that stimulates transcription myelin basic protein (MBP) gene for MBP a major component membrane. In 4-week-old Fyn-deficient mice, significantly reduced, electron microscopic analysis showed myelination delayed, compared with wild-type mice. mice had thinner, more irregular than wild-type. We found promoter activity by approximately sevenfold. region responsible transactivation located between nucleotides −675 −647 respect to start site. Proteins binding this were gel shift study, correlates during These results suggest important