Dopamine receptor interactions: some implications for the treatment of Parkinson's disease

摘要: Abstract Since the discovery that l-DOPA could alleviate symptoms of Parkinson's disease, it has been assumed striatum is site action dopamine formed from l-DOPA. However, for past 15 years, evidence accumulated to suggest also released by dendrites neurons in substantia nigra and D 1 receptors this region brain appear play an important role actions Activation may, part, explain some synergistic effects 2 agonists animal models disease. These are discussed light recent studies suggesting dopamine, acting on receptor subtypes, activates distinct efferent pathways striatum. Clinical these findings may have implications treatment