Extraction, interpretation and validation of information for comparing samples in metabolic LC/MS data sets

作者: Pär Jonsson , Stephen J. Bruce , Thomas Moritz , Johan Trygg , Michael Sjöström

DOI: 10.1039/B501890K

关键词:

摘要: LC/MS is an analytical technique that, due to its high sensitivity, has become increasingly popular for the generation of metabolic signatures in biological samples and building metaboli ...

参考文章(23)
Michael Sjöström, Svante Wold, Bengt Söderström, PLS DISCRIMINANT PLOTS Pattern Recognition in Practice. pp. 461- 470 ,(1986) , 10.1016/B978-0-444-87877-9.50042-X
Oliver Fiehn, Joachim Kopka, Peter Dörmann, Thomas Altmann, Richard N. Trethewey, Lothar Willmitzer, Metabolite profiling for plant functional genomics Nature Biotechnology. ,vol. 18, pp. 1157- 1161 ,(2000) , 10.1038/81137
John C. Lindon, Jeremy K. Nicholson, Elaine Holmes, Jeremy R. Everett, Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids Concepts in Magnetic Resonance. ,vol. 12, pp. 289- 320 ,(2000) , 10.1002/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W
E.M. Lenz, J. Bright, I.D. Wilson, A. Hughes, J. Morrisson, H. Lindberg, A. Lockton, Metabonomics, dietary influences and cultural differences: a 1H NMR-based study of urine samples obtained from healthy British and Swedish subjects Journal of Pharmaceutical and Biomedical Analysis. ,vol. 36, pp. 841- 849 ,(2004) , 10.1016/J.JPBA.2004.08.002
Helena Idborg-Björkman, Per-Olof Edlund, Olav M. Kvalheim, Ina Schuppe-Koistinen, Sven P. Jacobsson, Screening of biomarkers in rat urine using LC/electrospray ionization-MS and two-way data analysis. Analytical Chemistry. ,vol. 75, pp. 4784- 4792 ,(2003) , 10.1021/AC0341618
Robert S. Plumb, Chris L. Stumpf, Marc V. Gorenstein, Jose M. Castro-Perez, Gordon J. Dear, Maria Anthony, Brian C Sweatman, Susan C. Connor, John N. Haselden, Metabonomics: the use of electrospray mass spectrometry coupled to reversed‐phase liquid chromatography shows potential for the screening of rat urine in drug development Rapid Communications in Mass Spectrometry. ,vol. 16, pp. 1991- 1996 ,(2002) , 10.1002/RCM.813