Transition metal mediated synthesis of (±)-chuangxinmycin methyl ester
作者： Michael J. Dickens , Timothy J. Mowlem , David A. Widdowson , Alexandra M. Z. Slawin , David J. Williams
DOI: 10.1039/P19920000323
关键词:
摘要: Chromium mediated synthesis of 4-iodo-1-triisopropylsilylindole followed by 4-methoxycarbonyl-methylthiation palladium catalysed cross coupling with methoxycarbonylmethylthio(trialkyl)-stannane and aldol condensation gave the key α-thioacrylate intermediate 5. The Z-geometry major isomer 5 was determined X-ray crystal analysis. Closure ring C a novel fluoride ion formation 2a–3 bond completed short (±)-chuangxinmycin methyl ester 1(R = Me).
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