The synthesis of 4 - Substituted Indoles via arenetricarbonylchromium(0) complexes
作者： P.J. Beswick , C.S. Greenwood , T.J. Mowlem , G. Nechvatal , D.A. Widdowson
DOI: 10.1016/S0040-4020(01)86105-6
关键词: Indole test 、 Palladium 、 Medicinal chemistry 、 Electrophile 、 Halide 、 Catalysis 、 Yield (chemistry) 、 Transmetalation 、 Chromium 、 Chemistry 、 Organic chemistry
摘要: Abstract Lithiation of tricarbonyl-η 6 -(1-tri-isopropyisilylindote)chromium(0) and η -(1 -tri-isopropylsilyl-3-methoxymethylindole)tricarbonylchromium(0) followed by an electrophilic quench produced a series 4-substituted indole complexes. For the 4-acyl, -allyl -alkenyl analogues, transmetallation lithio- species to corresponding cupro- complexes reaction with appropriate halides (in alkenyl case palladium catalysis) gave in total, wide range 4-substitutents. The were decomplexed desilylated produce indoles moderate good overall yield.
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