Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules.

摘要: The genetic events that produce diversity in class I MHC genes and proteins has been investigated by using a family of closely related HLA-A alleles. Five coding for HLA-A2.2Y, HLA-A2.3, HLA-Aw68.2 have isolated. Exon sequences are compared with the known HLA-A2.1, HLA-A2.2F, HLA-A2.4, HLA-Aw68.1, HLA-Aw69. Pairwise comparison eight unique shows point mutation, reciprocal recombination, gene conversion all contributed significantly to diversification this These results those other studies emphasized role conversion. A predominance substitutions alpha 1 2 domains is found, consistent positive selection polymorphism being major factor fixation these In three cases examined, phenotypically identical gave nucleotide sequences, indicating most, if not all, detectable immunological methods. apparent stability suggests generating some alleles occurred before origin modern Homo sapiens.