Change of serum vascular adhesion protein-1 after glucose loading correlates to carotid intima-medial thickness in non-diabetic subjects
作者： Hung-Yuan Li , Mao-Shin Lin , Jung-Nan Wei , Chi Sheng Hung , Fu-Tien Chiang
DOI: 10.1016/J.CCA.2009.01.027
关键词:
摘要: Abstract Background We investigated if serum vascular adhesion protein-1 (SSAO/VAP-1) changed acutely following oral glucose loading and whether such changes are correlated with surrogate markers of atherosclerosis. Methods A total 115 non-diabetics subjects were enrolled for an tolerance test (OGTT). Carotid intima-medial thickness (IMT) was measured by ultrasonography. Serum SSAO/VAP-1 analyzed time-resolved immunofluorometric assay. thiobarbituric acid reactive substances (TBARS) advanced glycated end products (AGEs) fluorometric assays. Results increased significantly at 30 min after lasted to 2 h (p = 0.0005 p Conclusions in non-diabetic subjects. Change independently TBARS, AGEs, carotid IMT. Our findings suggest that acute change is a novel marker hyperglycemia-induced
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