Interesting coordination abilities of antiulcer drug famotidine and antimicrobial activity of drug and its cobalt(III) complex.

摘要: Crystal structure of a novel cobalt(III) complex with antiulcer drug famotidine and ethylenediamine was determined. This is the second transition metal resolved by single crystal X-ray analysis, in which shows different mode coordination than that observed other cases. Drug molecule coordinated to ion as tetradentate ligand through guanidine N6, thiazole N4, thioether S2 terminal N3 atom. Two NH(2) groups (N3H(2) N6H(2)) are deprotonated coordinates dianion. In asymmetric unit, one chloride anion water were found complete stoichiometry. The abundant atoms, can be involved hydrogen bond formation either acceptors or donors. Because that, great number bonds dominates packing. Beside bonds, there two interesting noncovalent interactions: CH(...)pi NH(...)pi within anion, stabilize structure. pi(...)pi stacking interactions between neighboring cations also observed. Antibacterial antifungal activity its newly synthesized against representative bacteria: Escherichia coli, Staphilococcus aureus Micrococcus lysodeikticus fungi: Aspergillus niger Candida albicans examined. results indicate higher selectivity famotidine-Co(III) complex, well better growth inhibitory (lower MIC values (MIC, minimal concentration)) comparison alone.