Assessment of skin microvascular function and dysfunction with laser speckle contrast imaging.

摘要: In recent years, skin microcirculation has been considered an easily accessible and potentially representative vascular bed to evaluate understand the mechanisms of microvascular function dysfunction.1–3 Vascular dysfunction (including impaired endothelium-dependent vasodilation) induced by different pathologies is evident in cutaneous circulation.4–7 It suggested that may mirror generalized systemic magnitude underlying mechanisms.1 Furthermore, minimally invasive skin-specific methodologies using laser systems make circulation a useful translational model for investigating physiology pathophysiology either disease itself or other diseases such as vascular, rheumatologic, pneumologic. To date, used investigate variety diseased states, including hypercholesterolemia,8 Alzheimer disease,9 carpal tunnel syndrome,10 schizophrenia,11 hypertension,6 renal disease,12 type 2 diabetes,13 peripheral disease,14 atherosclerotic coronary artery disease,2 heart failure,15 sclerosis,16 obesity,17 primary aging,18,19 sleep apnea.20 Assessment can be done both noninvasive techniques. Among techniques, are mainly used.21 The development speckle contrast imaging (LSCI) technique monitoring enables its use surrogate end point clinical trials. LSCI allows noncontact, real-time, blood flow changes.22,23 Recent evidence shown dramatically reduces variability measurements compared with Doppler flowmetry (LDF), making fascinating tool facilitate studies routine.23,24 this review, we describe …