Ondansetron in the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a prospective randomized study.

摘要: Background: There is an increased incidence of postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy. The aim the study was to evaluate efficacy intravenous ondansetron, a 5-HT anatagonist, for prevention from PONV Methods: Sixty-eight patients were entered into study. Thirty-six randomized receive single dose 4 mg ondansetron before extubation. Thirty-two received no prophylaxis. differences in terms sex ratio, age, ASA status, duration operation between two groups. Patients interviewed by independent observer assess pain using visual analog score. Patients' satisfaction scores procedure measured. Results: complication series. Pain at 2 24 h analgesics consumption not different For who mean (SD) score 1.5 (1.2) 1.4 (1.4), respectively. control group (1.0) 1.2 (0.5), also difference episodes usage antiemetics Both groups equally satisfied with procedures. Conclusion: Routine use does reduce