Antiemetic efficacy of prophylactic ondansetron in laparoscopic cholecystectomy. A randomised, double-blind, placebo-controlled trial.

摘要: The antiemetic efficacy of ondansetron given prophylactically was investigated in a randomised, double-blind, placebo-controlled trial 63 patients undergoing laparoscopic cholecystectomy. received intravenously prior to anaesthesia either 4 mg or placebo. same standardised general anaesthetic technique used. Nausea, emetic episodes and the need for rescue medication were recorded 24 h postoperatively. Nausea experienced by 64% group 56% placebo group, occurred 45% 50% two groups, respectively. proportions 44%, No clinically important adverse events observed. In conclusion, dosage did not prevent postoperative nausea vomiting after