Peptidyl inhibitors of viral proteases

摘要: The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH) 2 ; R 1 lower alkyl (optionally substituted by halo, cyano, alkylthio, aryl-lower aryl heteroaryl), alkenyl alkynyl; optionally hydroxy, carboxy, aryl, aminocarbonyl cycloalkyl; and 3 hydrogen alkyl; together represent di- trimethylene hydroxy; 4 cycloalkyl, cyano-lower alkylthio alkylthio), alkenyl, 5 alkylthio) 6 7 cycloalkyl) 8 carboxy aryl; 9 alkylcarbonyl, carboxy-lower arylcarbonyl, alkylsulphonyl, arylsulphonyl, alkoxycarbonyl al koxycarbonyl, salts acidic compounds I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for treatment prophylaxis infections caused Hepatitis C, G human GB viruses.