Body and brain growth following continuous perinatal administration of arginine- and lysine-vasopressin to the homozygous brattleboro rat

摘要: Using a recently developed controlled-drug-delivery implantation technique, arginine-vasopressin (AVP) or lysine-vasopressin (LVP) was administered to homozygous (HOM) Brattleboro rats throughout pregnancy in order study the influence of compensation for deficiency AVP on body and brain development their HOM offspring. This mutant is retarded both growth from neonatal period onwards. In one subgroup LVP-treatment continued postnatally by means subcutaneous pups. treatment had no growth-stimulating effect either pup weight at day postnatal growth, nor did it affect noticeably eye opening, number parameters measured month age. LVP treatment, contrast, resulted higher weights birth, which could be maintained if pups were reared with Wistar foster-mother. At age as well still larger treated Although cerebellar than untreated this group, DNA content gross morphology, known impaired rats, not changed. pups, maternal AVP-treatment beginning 15 pregnancy, inhibiting rather effects, high-lighting different effects created these two peptides stages development.