Polycystic kidney disease evaluation by magnetic resonance imaging in ischemia-reperfusion injured PKD1 knockout mouse model: comparison of T2-weighted FSE and true-FISP.
作者： Xiangzhi Zhou , Haihua Bao , Ayumi Takakura , Jing Zhou , Mitchell Albert
DOI: 10.1097/RLI.0B013E3181BE3501
关键词:
摘要: Objective: To investigate the efficacy of true fast imaging with steady state precession (true-FISP) compared T2-weighted spin echo (T2W-FSE) in monitoring changes cyst volume and renal expansion an ischemia reperfusion (IR) injured PKD1 knockout (IKO) mouse model. Materials Methods: The animal study was approved by local institutional authority. A total 24 mice (14 IKO 10 control mice) were sequentially scanned on a 4.7-T scanner from 4 to 12 weeks after IR injury cysts kidney volumes measured true-FISP T2W-FSE MR images. Signal-to-noise ratio (SNR) contrast-to-noise (CNR) calculated for images generated both methods. Results: Cyst SNR CNR significantly higher than employing sequence (P < 0.05). Both methods demonstrated increase as well growth at different time points strongly correlated between measurements (r = 0.99, r 0.97). Conclusion: method offers shorter scan times tissue contrast T2W-FSE. sequences have identical accuracy measuring PKD.
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