Chemical Regulation of the Apoptosome: New Alternative Treatments for Cancer
作者： Kelvin Cain
DOI: 10.1007/978-90-481-3415-1_3
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摘要: Many chemotherapeutic drugs and treatments initiate apoptotic cell death by inducing the release of cytochrome c from mitochondria, which activates Apaf-1. This large (approximately 130–140 kDa) protein is a mammalian homolog CED-4, an essential involved in programmed nematode Caenorhabditis elegans. Cytochrome Apaf-1, oligomerizes to form Apaf-1 apoptosome complex, recruits caspase-9, initiator caspase, holoenzyme complex.
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