Impact of heart rate on central aortic pressures and hemodynamics: analysis from the CAFE (Conduit Artery Function Evaluation) study: CAFE-Heart Rate.

摘要: Objectives The CAFE (Conduit Artery Function Evaluation) study showed less effective central aortic pressure lowering with atenolol-based therapy versus amlodipine-based in people hypertension. present examined the importance of heart rate (HR) as a determinant this effect. Background Recent analyses have suggested that beta-blockers are at reducing cardiovascular events than alternative blood (BP)-lowering therapies. There has been much debate about mechanism for shortfall benefit and specifically role HR by beta-blockers. Methods Central pressures were derived from brachial radial pulse wave analysis 2,073 patients, 7,146 measurements recorded analyzed over follow-up up to 4 years. Results was no impact on systolic or pressures; however, there highly significant inverse relationship between (p Conclusions When comparing beta-blocker–based treatments other BP-lowering strategies, reduction is major accounting per unit change pressure.