Lyme disease and the peripheral nervous system

摘要: Lyme disease, the multisystem infectious disease caused by tick-borne spirochete Borrelia burgdorferi, causes a broad variety of peripheral nerve disorders, including single or multiple cranial neuropathies, painful radiculopathies, and diffuse polyneuropathies. Virtually all appear to be varying manifestations mononeuropathy multiplex. Diagnosis requires that patient should have had possible exposure only known vectors, Ixodes ticks, also either other pathognomonic clinical laboratory evidence exposure. Treatment with antimicrobial regimens is highly effective. The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies several constituent molecules raise intriguing possibilities.