Gene Expression Profiles of Sporadic Canine Hemangiosarcoma Are Uniquely Associated with Breed

摘要: The role an individual's genetic background plays on phenotype and biological behavior of sporadic tumors remains incompletely understood. We showed previously that lymphomas from Golden Retrievers harbor defined, recurrent chromosomal aberrations occur less frequently in other dog breeds, suggesting spontaneous canine provide suitable models to define how heritable traits influence cancer genotypes. Here, we report a complementary approach using gene expression profiling naturally occurring endothelial sarcoma dogs (hemangiosarcoma). Naturally hemangiosarcomas clustered separately those non-Golden Retrievers, with contributions transcription factors, survival pro-inflammatory angiogenic genes, which were exclusively present hemangiosarcoma not or normal cells (i.e., they due simply variation these genes among breeds). Vascular Endothelial Growth Factor Receptor 1 (VEGFR1) was preferentially enriched within known pathways derived set enrichment analysis when characterizing versus breeds. Heightened VEGFR1 also apparent at the protein level targeted inhibition increased proliferation but Our results suggest factors mold phenotypes, consequently sporadic, tumors.