作者: Mario Spagnuolo , Bernard Pasternack , Angelo Taranta
DOI: 10.1056/NEJM197109162851201
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摘要: Abstract The rheumatic-fever recurrence rate per streptococcal infection was studied in 393 patients whom 711 infections and 123 recurrences developed. Factors were evaluated for their relation to the by means of statistical technics that allowed testing significance a given factor while holding others constant; thus, each independently from others. Symptoms pharyngitis (sore throat fever) significantly associated with high rate, whereas magnitude rise antistreptolysin-O titer not. Young age and, particularly, short interval since preceding rheumatic attack, also recurrence, as existing heart disease, number previous attacks oral (rather than parenteral) administration drug prophylaxis. effects overcrowding, yearly family income, welfare status, fever siblings ethnic group not significant.