作者: Fiona M. Guerra , Natasha S. Crowcroft , Lindsay Friedman , Shelley L. Deeks , Scott A. Halperin
DOI: 10.1016/J.VACCINE.2018.01.002
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摘要: Abstract Introduction Most infants are born with immunity to measles through maternal antibodies transferred in pregnancy, which decay over time. However, elimination settings, where does not circulate endemically and most is from immunization rather than infection, antibody levels lower. This results infant that wanes earlier, a wider susceptibility gap between non-eliminated settings. We aimed systematically quantify the extent duration of protection settings have sustained elimination. Methods conducted systematic review studies waning searched MEDLINE, Embase, CINAHL, Scopus, BIOSIS Previews, Global Health databases for relevant studies. Studies were included if they set countries had eliminated ≥3 years, study cohort healthy, full-term, unvaccinated ≤12 months, healthy mothers, reported measure infants. assessed quality using MetaQAT tool. Results identified 4692 unique citations, eight met inclusion criteria. One anti-measles cord blood, six sera, one both. Two 80 100% protected at birth. no amongst 3–7 month old infants, another limited >4 months. The remaining proportion detected antibody, but immune. Conclusion Although limited, these data suggest elimination, some susceptible well before age routine immunization. Setting-specific seroprevalence vaccine effectiveness required evaluate this different jurisdictions.