Measles Antibody Levels in Young Infants
作者： Michelle Science , Rachel Savage , Alberto Severini , Elizabeth McLachlan , Stephanie L. Hughes
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摘要: BACKGROUND: Infants are often assumed to be immune measles through maternal antibodies transferred during pregnancy and, in many countries, receive their first measles-containing vaccine at 12 15 months. Immunity may wane before this time measles-eliminated settings, placing infants risk for and complications. We investigated humoral immunity METHODS: selected sera collected a tertiary pediatric hospital from RESULTS: Of 196 infant sera, 56% (110 of 196) were boys, 35% (69 with underlying medical conditions. In the month, 20% (5 25) had below protective threshold, which increased 92% (22 24) by 3 By 6 months, all titers threshold. multivariable analysis, age was strongest predictor susceptibility (odds ratio = 2.13 each additional month increase; 95% confidence interval: 1.52–2.97). CONCLUSIONS: Most susceptible months elimination setting. Our findings inform important policy discussions relating timing dose postexposure prophylaxis recommendations.
aappublications.org参考文章(35)
Patrícia Oliveira Viana, Erika Ono, Maria Isabel Saraiva Dinelli, Beatriz Tavares Costa-Carvalho, Amélia Miyashiro Nunes dos Santos, Nelson Sass, Maria Isabel de Moraes-Pinto, Maternally acquired IgG immunity in neonates born to renal transplanted women Vaccine. ,vol. 33, pp. 3104- 3109 ,(2015) , 10.1016/J.VACCINE.2015.04.104
Sarah E. Wilson, Kamran Khan, Vladimir Gilca, Jennifer Miniota, Shelley L. Deeks, Gillian Lim, Rose Eckhardt, Shelly Bolotin, Natasha S. Crowcroft, Global travel patterns and risk of measles in Ontario and Quebec, Canada: 2007–2011 BMC Infectious Diseases. ,vol. 15, pp. 341- 341 ,(2015) , 10.1186/S12879-015-1039-0
Gaston De Serres, Jean R. Joly, Micheline Fauvel, François Meyer, Benoit Mâsse, Nicole Boulianne, Passive immunity against measles during the first 8 months of life of infants born to vaccinated mothers or to mothers who sustained measles Vaccine. ,vol. 15, pp. 620- 623 ,(1997) , 10.1016/S0264-410X(96)00283-6
Gaston De Serres, Shalini Desai, Amanda Shane, Joanne Hiebert, Manale Ouakki, Alberto Severini, Measles in Canada Between 2002 and 2013. Open Forum Infectious Diseases. ,vol. 2, ,(2015) , 10.1093/OFID/OFV048
Rolf M. Zinkernagel, Maternal Antibodies, Childhood Infections, and Autoimmune Diseases The New England Journal of Medicine. ,vol. 345, pp. 1331- 1335 ,(2001) , 10.1056/NEJMRA012493
R. T. Chen, L. E. Markowitz, P. Albrecht, J. A. Stewart, L. M. Mofenson, S. R. Preblud, W. A. Orenstein, Measles Antibody: Reevaluation of Protective Titers The Journal of Infectious Diseases. ,vol. 162, pp. 1036- 1042 ,(1990) , 10.1093/INFDIS/162.5.1036
HILTON WHITTLE, PETER AABY, BADARA SAMB, BADARA CISSÉ, FULLOE KANTEH, MASSERIGNE SOUMARÉ, HENRIK JENSEN, JOHN BENNETT, FRANÇOIS SIMONDON, Poor serologic responses five to seven years after immunization with high and standard titer measles vaccines. Pediatric Infectious Disease Journal. ,vol. 18, pp. 53- 57 ,(1999) , 10.1097/00006454-199901000-00013
Paul Albrecht, Francis A. Ennis, Edward J. Saltzman, Saul Krugman, Persistence of maternal antibody in infants beyond 12 months: Mechanism of measles vaccine failure The Journal of Pediatrics. ,vol. 91, pp. 715- 718 ,(1977) , 10.1016/S0022-3476(77)81021-4
G. GONÇALVES, F. T. CUTTS, M. HILLS, H. REBELO-ANDRADE, F. A. TRIGO, H. BARROS, Transplacental transfer of measles and total IgG. Epidemiology and Infection. ,vol. 122, pp. 273- 279 ,(1999) , 10.1017/S0950268899002046
B.J. Cohen, D. Doblas, N. Andrews, Comparison of plaque reduction neutralisation test (PRNT) and measles virus-specific IgG ELISA for assessing immunogenicity of measles vaccination. Vaccine. ,vol. 26, pp. 6392- 6397 ,(2008) , 10.1016/J.VACCINE.2008.08.074