Progesterone induction of metallothionein-IIA gene expression.
作者： Emily P. Slater , Andrew C. B. Cato , Michael Karin , John D. Baxter , Miguel Beato
DOI: 10.1210/MEND-2-6-485
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摘要: Expression of the metallothionein gene is known to be induced by glucocorticoids in a variety cells. Here we show that human cell lines containing functional progesterone receptors, endogenous metallothionein-IIA (hMTIIA) inducible synthetic progestins R5020 and medroxy-progesterone acetate. That this effect reflects direct interaction with supported our finding partially purified receptor binds promoter region vitro. The limits DNase I footprint guanine residues protected methylation studies are similar those previously described for glucocorticoid receptor. Thus, hormone regulatory element can mediate regulation both progestins, as does mouse mammary tumor virus
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