CREB in the Mouse SCN: A Molecular Interface Coding the Phase-Adjusting Stimuli Light, Glutamate, PACAP, and Melatonin for Clockwork Access
作者： Charlotte von Gall , Giles E. Duffield , Michael H. Hastings , Michael D. A. Kopp , Faramarz Dehghani
DOI: 10.1523/JNEUROSCI.18-24-10389.1998
关键词:
摘要: The suprachiasmatic nucleus (SCN) is a central pacemaker in mammals, driving many endogenous circadian rhythms. An important target the regulation of hormonal message for darkness, rhythm melatonin synthesis. clock within SCN synchronized to environmental light/dark cycles by photic information conveyed via retinohypothalamic tract (RHT) and nocturnal signal that acts feedback loop. We investigated how intersects with temporally gated resetting actions two RHT transmitters, pituitary adenylate cyclase-activating polypeptide (PACAP) glutamate. analyzed immunocytochemically inducible phosphorylation transcription factor Ca2+/cAMP response element-binding protein (CREB) melatonin-proficient (C3H) melatonin-deficient (C57BL) mouse strain. In vivo, light-induced phase shifts locomotor activity were consistently accompanied CREB both strains. However, middle subjective nighttime, light induced larger delays C57BL than C3H mice. vitro, PACAP glutamate strains, being more effective during late daytime nighttime. Melatonin suppressed PACAP- but not glutamate-induced CREB. distinct temporal domains which induce imply transition switches sensitivity between these transmitters. Because are different mice, windows set independently rhythmic signal.
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