Transcriptional Mechanisms Underlying the Mammalian Circadian Clock

摘要: The mammalian ‘master’ pacemaker is seated in the suprachiasmatic nuclei (SCN), a bilateral hypothalamic structure above optic chiasm that heterogeneous conglomerate of ~ 20,000 neurons. Within SCN cells lies molecular basis circadian timekeeping: clock proteins form interlocking transcriptional feedback loops, and drive sustain rhythmic expression their cognate genes as well other clock-controlled (ccg). In addition to SCN, this intracellular common element many oscillating tissues central nervous system (CNS) periphery hierarchy. review we discuss nature themolecular clock,the neurotransmitter systems actuate entrainment, signaling events leading activation programs.