Bariatric surgery reduces urinary albumin excretion in diabetic nephropathy: a systematic review and meta-analysis

摘要: Abstract Background Bariatric surgery is found to prevent type 2 diabetes, improve glycemic control, and decrease long-term incidence of microvascular macrovascular complications in obese persons. However, its effect on urinary albumin excretion (UAE) patients with diabetic nephropathy (DN) still unknown. This a systematic review meta-analysis observational studies bariatric change UAE diabetes. Objective To explore whether there improvement after surgery. Methods We comprehensively searched the databases MEDLINE, Embase, Cochrane. The inclusion criteria were published evaluating effects DN at baseline. primary outcome was pre- postbariatric as characterized by albumin-to-creatinine ratio albuminuria. A comparing postsurgery performed. Results From 65 full-text articles, 15 met our criteria, 11 included based random model. There significant reduction mean difference –6.60 mg/g creatinine (95% CI –9.19 –4.02; P Conclusion significantly decreases DN. conventional or intensive care diabetes should be done.