Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques.

摘要: Aging and certain viral infections can negatively impact humoral responses in humans. To further develop the nonhuman primate (NHP) model for investigating B cell dynamics human aging infectious disease, a flow cytometric panel was developed to characterize circulating rhesus subsets. Significant differences between macaque cells included proportions of within IgD+ switched memory populations prominent CD21-CD27+ unswitched population detected only macaques. We then utilized expanded analyze alterations associated with acute simian immunodeficiency virus (SIV) infection NHP model. In study, distinct patterns subset frequencies were observed macaques aged one five years compared those ages 5 30 years. SIV absolute number dramatically reduced following infection, but recovered four weeks infection. Thereafter, activated progressively increased; these significantly correlated magnitude SIV-specific IgG responses, coincided impaired maturation anti-SIV antibody avidity, as previously reported HIV-1 These observations validate investigation mechanisms responsible immunosenescence disease.