Apoptotic neutrophils are phagocytosed by fibroblasts with participation of the fibroblast vitronectin receptor and involvement of a mannose/fucose-specific lectin.

摘要: The fate of neutrophils (PMNs) at sites inflammation is important to our understanding many disease processes. Previously, it had been widely assumed that extravasated PMNs inevitably disintegrated before their fragments were removed by local phagocytes, but we have recently described an alternative process whereby senescent undergo apoptosis (programmed cell death). This leads macrophage (Mphi) ingestion the intact a novel phagocytic recognition process. In this study, show monolayers fibroblasts also can selectively phagocytose apoptotic and involves two distinct mechanisms: one uses vitronectin receptor, as in Mphi PMNs; other mannose/fucose-specific lectin, which plays no part phagocytosis PMNs. direct interactions between demonstrated herein may implications for relationship scarring diseases.