The allergic march from Staphylococcus aureus superantigens to immunoglobulin E.

摘要: Staphylococcus aureus is a commensal bacterium in the respiratory tract mucosa of most people and infects skin atopic dermatitis patients. This might imply symbiotic relationship between host or standoff bacterial infection immune system. But superantigens produced by S. these locations are particular interest because they strongly implicated pathogenesis allergic disorders airway disease. They appear to act locally conditions stimulating polyclonal T cell B proliferation driving somatic hypermutation, class switching immunoglobulin (Ig) E production allergen-specific IgE mucosal cells. antibodies directed against ('superallergens') themselves engender chronic inflammation persistent sensitization conventional allergens mast cells antigen-presenting tissues dermatitis, rhinitis asthma. Moreover, inhibit activity regulatory that normally control inflammation, generate state steroid resistance confounds treatment