Identification and differential expression of microRNAs in the ovaries of pigs (Sus scrofa) with high and low litter sizes
作者： L. Huang , Z. J. Yin , Y. F. Feng , X. D. Zhang , T. Wu
DOI: 10.1111/AGE.12452
关键词:
摘要: Summary Litter size affects profitability in the swine industry. Mammalian ovaries play important roles during reproduction, including ovulation and hormone secretion, which are tightly regulated by specific microRNAs (miRNAs). In this study, we investigated effects of miRNAs on porcine litter size. We compared ovarian Yorkshire pigs with high (YH) low (YL) sizes using Solexa sequencing technology. identified 327 320 YH YL respectively. A total 297 were co-expressed; 30 23 respectively specifically expressed two libraries. 83 novel predicted; 37 obtained, 21 upregulated 16 downregulated YL. Additionally, 19 628 19 250 target genes predicted libraries The results revealed that (i.e., miR-224, miR-99a, let-7c, miR-181c, miR-214 miR-21) may affect study will help gaining understanding role regulation.
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