ANTIGENIC DRIFT OF THE H1 SUBTYPE HAEMAGGLUTININ FROM 1977 TO 1980

摘要: Publisher Summary A previous analysis of an extensive set laboratory-selected antigenic mutants influenza virus A/PR/8/34 (H1N1 subtype) defined the location 4 sites on haemagglutinin. This chapter discusses experiment in which to estimate relevance these nature variation, occurs during evolution man, a sequence domain series recent H1 subtype strains was performed. In study, amino acid HA1subunit A/USSR/90/77, A/Brazil/11/78, A/Lackland/3/78, A/England/333/80, and A/India/6263/80 derived by nucleotide virion RNA. The deduced substitutions observed five were compared definitive HA1 haemagglutinin A/PR/8/34. From it found that forty-two occurred between A/USSR/90/77 but no insertions or deletions observed. degree substitution constitutes evolutionary drift 13%.