Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.
作者： Lin Zhang , Jose R. Conejo-Garcia , Dionyssios Katsaros , Phyllis A. Gimotty , Marco Massobrio
DOI: 10.1056/NEJMOA020177
关键词:
摘要: Background Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not established. Methods We performed immunohistochemical analysis of 186 frozen specimens from advanced-stage carcinomas to assess the distribution and conducted analyses. Molecular analyses were some tumors by real-time polymerase chain reaction. Results CD3+ detected within tumor-cell islets (intratumoral cells) 102 (54.8 percent); they undetectable 72 (38.7 remaining 12 (6.5 percent) could be evaluated. There significant differences distributions progression-free survival overall according presence or absence intratumoral (P<0.001 for both comparisons). The five-year rate was 38.0 percent among patients whose contained 4.5 ...
elsevier.es参考文章(46)
Ralph S. Freedman, Chris D. Platsoucas, Immunotherapy for peritoneal ovarian carcinoma metastasis using ex vivo expanded tumor infiltrating lymphocytes Cancer treatment and research. ,vol. 82, pp. 115- 146 ,(1996) , 10.1007/978-1-4613-1247-5_8
F. R. Balkwill, J. Hadley, G. W. H. Stamp, R. P. M. Negus, Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines. American Journal of Pathology. ,vol. 150, pp. 1723- 1734 ,(1997)
Douglas J. Schwartzentruber, Kathleen C. Barracchini, Yasmine M. Hijazi, Roya D. Dadmarz, Steven A. Rosenberg, Arnold Mixon, Aida Ordoubadi, Michael A. Steller, Carolyn O. Thompson, Tumor-infiltrating lymphocytes from human ovarian cancer patients recognize autologous tumor in an MHC class II-restricted fashion. The cancer journal from Scientific American. ,vol. 2, pp. 263- 272 ,(1996)
Manabu Nakashima, Kenzo Sonoda, Takeshi Watanabe, Inhibition of cell growth and induction of apoptotic cell death by the human tumor-associated antigen RCAS1. Nature Medicine. ,vol. 5, pp. 938- 942 ,(1999) , 10.1038/11383
Ursula Pertl, Andrew D. Luster, Nissi M. Varki, Dirk Homann, Gerhard Gaedicke, Ralph A. Reisfeld, Holger N. Lode, IFN-γ-Inducible Protein-10 Is Essential for the Generation of a Protective Tumor-Specific CD8 T Cell Response Induced by Single-Chain IL-12 Gene Therapy The Journal of Immunology. ,vol. 166, pp. 6944- 6951 ,(2001) , 10.4049/JIMMUNOL.166.11.6944
G H Windbichler, H Hausmaninger, W Stummvoll, A H Graf, C Kainz, J Lahodny, U Denison, E Müller-Holzner, C Marth, Interferon-gamma in the first-line therapy of ovarian cancer: a randomized phase III trial. British Journal of Cancer. ,vol. 82, pp. 1138- 1144 ,(2000) , 10.1054/BJOC.1999.1053
G H Shen, M Ghazizadeh, O Kawanami, H Shimizu, E Jin, T Araki, Y Sugisaki, Prognostic significance of vascular endothelial growth factor expression in human ovarian carcinoma. British Journal of Cancer. ,vol. 83, pp. 196- 203 ,(2000) , 10.1054/BJOC.2000.1228
Hiroshi Nagura, Haruo Ohtani, Akio Ohuchi, Kenichi Shiiba, Yoshitaka Naito, Kazuya Saito, Katsunori Saigenji, CD8+ T Cells Infiltrated within Cancer Cell Nests as a Prognostic Factor in Human Colorectal Cancer Cancer Research. ,vol. 58, pp. 3491- 3494 ,(1998)
Amy E. Loercher, John J. Kavanagh, Ralph S. Freedman, Micheal A. Nash, Chris D. Platsoucas, Identification of an IL-10-Producing HLA-DR-Negative Monocyte Subset in the Malignant Ascites of Patients with Ovarian Carcinoma That Inhibits Cytokine Protein Expression and Proliferation of Autologous T Cells Journal of Immunology. ,vol. 163, pp. 6251- 6260 ,(1999)
J. G. Cyster, Chemokines and Cell Migration in Secondary Lymphoid Organs Science. ,vol. 286, pp. 2098- 2102 ,(1999) , 10.1126/SCIENCE.286.5447.2098