NPAT links cyclin E-Cdk2 to the regulation of replication-dependent histone gene transcription.
作者： Jiyong Zhao , Brian K Kennedy , Brandon D Lawrence , David A Barbie , A Gregory Matera
DOI: 10.1101/GAD.827700
关键词:
摘要: In eukaryotic cells, histone gene expression is one of the major events that mark entry into S phase. While this process tightly linked to cell cycle position, how it regulated by machinery not known. Here we show NPAT, a substrate cyclin E–Cdk2 complex, associated with human replication-dependent clusters on both chromosomes 1 and 6 in We demonstrate NPAT activates transcription activation dependent promoter elements (SSCSs) previously proposed mediate cycle–dependent transcription. Cyclin E also loci, stimulates NPAT-mediated Thus, our results involved key phase event provide link between
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Marzluff Wf, Histone 3' ends: essential and regulatory functions. Gene Expression. ,vol. 2, pp. 93- 97 ,(1992)
Wei Jiang, Gretchen Jimenez, Nicholas J Wells, Thomas J Hope, Geoffrey M Wahl, Tony Hunter, Rikiro Fukunaga, PRC1: A Human Mitotic Spindle–Associated CDK Substrate Protein Required for Cytokinesis Molecular Cell. ,vol. 2, pp. 877- 885 ,(1998) , 10.1016/S1097-2765(00)80302-0
E.W. Lam, R.J. Watson, An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription. The EMBO Journal. ,vol. 12, pp. 2705- 2713 ,(1993) , 10.1002/J.1460-2075.1993.TB05932.X
M Di Fruscio, H Weiher, B C Vanderhyden, T Imai, T Shiomi, T A Hori, R Jaenisch, D A Gray, Proviral inactivation of the Npat gene of Mpv 20 mice results in early embryonic arrest. Molecular and Cellular Biology. ,vol. 17, pp. 4080- 4086 ,(1997) , 10.1128/MCB.17.7.4080
L Dailey, S B Roberts, N Heintz, RNA polymerase II transcription factors H4TF-1 and H4TF-2 require metal to bind specific DNA sequences. Molecular and Cellular Biology. ,vol. 7, pp. 4582- 4584 ,(1987) , 10.1128/MCB.7.12.4582
A J van Wijnen, F M van den Ent, J B Lian, J L Stein, G S Stein, Overlapping and CpG methylation-sensitive protein-DNA interactions at the histone H4 transcriptional cell cycle domain: distinctions between two human H4 gene promoters. Molecular and Cellular Biology. ,vol. 12, pp. 3273- 3287 ,(1992) , 10.1128/MCB.12.7.3273
D Resnitzky, M Gossen, H Bujard, S I Reed, Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Molecular and Cellular Biology. ,vol. 14, pp. 1669- 1679 ,(1994) , 10.1128/MCB.14.3.1669
H L Sive, N Heintz, R G Roeder, Multiple sequence elements are required for maximal in vitro transcription of a human histone H2B gene. Molecular and Cellular Biology. ,vol. 6, pp. 3329- 3340 ,(1986) , 10.1128/MCB.6.10.3329
F Oswald, T Dobner, M Lipp, The E2F transcription factor activates a replication-dependent human H2A gene in early S phase of the cell cycle. Molecular and Cellular Biology. ,vol. 16, pp. 1889- 1895 ,(1996) , 10.1128/MCB.16.5.1889
Colyn Crane-Robinson, Alan P. Wolffe, Immunological analysis of chromatin: FIS and CHIPS Trends in Genetics. ,vol. 14, pp. 477- 480 ,(1998) , 10.1016/S0168-9525(98)01621-7