Is calcaneal quantitative ultrasound useful as a prescreen stratification tool for osteoporosis

摘要: Calcaneal quantitative ultrasound (QUS) is attractive as a prescreening tool for osteoporosis, alternative to dual-energy X-ray absorptiometry. We investigated the literature of usability calcaneal QUS. found large heterogeneity between studies and uncertainty about cutoff, device, measured variable. Despite osteoporosis-related fractures being major health issue, osteoporosis remains underdiagnosed. Dual-energy absorptiometry (DXA) hip or spine currently preferred method diagnosis but limited by low accessibility. QUS assessing bone DXA. The aim this systematic review was explore prescreen stratification assessment osteoporosis. Studies that evaluated with DXA gold standard included. extracted data from included calculate number DXAs saved misclassification rates at cutoffs equal high sensitivity and/or specificity. percentage persons misclassified were measures usability. 31 studies. heterogeneous regarding study characteristics. Analyses showed wide spectrum (2.7–68.8 %) (0–12.4 depending on strategy characteristics, variable, cutoff. potentially useful However, there no consensus Overall, sufficient evidence recommend specific cutoff provides certainty level enough rule in out algorithm must be based device-specific are validated populations which they intended used.