Relation of α2-macroglobulin and other antiproteases to the clinical features of acute pancreatitis

摘要: alpha 2-macroglobulin is probably the most important of antiproteases in plasma. In this study, relationships plasma to clinical features acute pancreatitis as well levels other antiproteases, immunoglobulins, and immunoreactive trypsin, were investigated 55 patients with pancreatitis. The mean level 395 samples from was 2.12 g/liter compared 2.41 29 healthy subjects 2.93 17 septicemia. Plasma lower 12 severe than 43 mild attacks, lowest three fatal attacks less half normal range. Lowest recorded at a time 3 days after admission 5 9 those attacks. contrast, 1-proteinase inhibitor antichymotrypsin C-reactive protein increased above during attack, significantly more so IgA, IgG, IgM remained within range or increased. pancreatitis, trypsin elevated for longer although there little initial difference levels. These data suggest that decreasing course are due specific mechanism unrelated, part, any generalized effect on synthesis. formation rapidly cleared complexes between active proteases tenable explanation depletion levels, but significance changes remains unclear.