μ-Opioid receptor stimulation in the medial subnucleus of the tractus solitarius inhibits gastric tone and motility by reducing local GABA activity

作者: Melissa A. Herman , Alisa Alayan , Niaz Sahibzada , Barbara Bayer , Joseph Verbalis

DOI: 10.1152/AJPGI.00038.2010

关键词:

摘要: We examined the effects of altering μ-opioid receptor (MOR) activity in medial subnucleus tractus solitarius (mNTS) on several gastric end points including intragastric pressure (IGP), f...

参考文章(54)
R. A. Travagli, R. A. Gillis, C. D. Rossiter, S. Vicini, Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus. American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 260, ,(1991) , 10.1152/AJPGI.1991.260.3.G531
L Rinaman, JP Card, JS Schwaber, RR Miselis, Ultrastructural demonstration of a gastric monosynaptic vagal circuit in the nucleus of the solitary tract in rat The Journal of Neuroscience. ,vol. 9, pp. 1985- 1996 ,(1989) , 10.1523/JNEUROSCI.09-06-01985.1989
S. R. Glaum, R. J. Miller, Hyewhon Rhim, Selective opioid agonists modulate afferent transmission in the rat nucleus tractus solitarius. Journal of Pharmacology and Experimental Therapeutics. ,vol. 264, pp. 795- 800 ,(1993)
B.H. Manning, M.J. Morgan, K.B.J. Franklin, Morphine analgesia in the formalin test: evidence for forebrain and midbrain sites of action. Neuroscience. ,vol. 63, pp. 289- 294 ,(1994) , 10.1016/0306-4522(94)90023-X
Donatella Mutolo, Fulvia Bongianni, Elenia Cinelli, Giovanni A. Fontana, Tito Pantaleo, Modulation of the cough reflex by antitussive agents within the caudal aspect of the nucleus tractus solitarii in the rabbit American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 295, ,(2008) , 10.1152/AJPREGU.00184.2008
Tracie L. Pierce, Martin W. Wessendorf, Immunocytochemical mapping of endomorphin-2-immunoreactivity in rat brain Journal of Chemical Neuroanatomy. ,vol. 18, pp. 181- 207 ,(2000) , 10.1016/S0891-0618(00)00042-9
Hong Gao, Nicholas R. Glatzer, Kevin W. Williams, Andrei V. Derbenev, Dan Liu, Bret N. Smith, Morphological and electrophysiological features of motor neurons and putative interneurons in the dorsal vagal complex of rats and mice. Brain Research. ,vol. 1291, pp. 40- 52 ,(2009) , 10.1016/J.BRAINRES.2009.07.024
Sheryl Martin-Schild, Arnold A. Gerall, Abba J. Kastin, James E. Zadina, Differential distribution of endomorphin 1- and endomorphin 2-like immunoreactivities in the CNS of the rodent. The Journal of Comparative Neurology. ,vol. 405, pp. 450- 471 ,(1999) , 10.1002/(SICI)1096-9861(19990322)405:4<450::AID-CNE2>3.0.CO;2-#