Vasopressors for cardiopulmonary resuscitation. Does pharmacological evidence support clinical practice
作者： Peter E. Penson , William R. Ford , Kenneth J. Broadley
DOI: 10.1016/J.PHARMTHERA.2007.03.003
关键词:
摘要: Adrenaline (epinephrine) has been used for cardiopulmonary resuscitation (CPR) since 1896. The rationale behind its use is thought to be alpha-adrenoceptor-mediated peripheral vasoconstriction, causing residual blood flow diverted coronary and cerebral circulations. This protects these tissues from ischaemic damage increases the likelihood of restoration spontaneous circulation. Clinical trials have not demonstrated any benefit adrenaline over placebo as an agent resuscitation. deleterious effects in setting resuscitation, predictable promiscuous pharmacological profile. article discusses relevant pharmacology context CPR. Experimental clinical evidences alternative vasopressor agents are given, properties ideal discussed.
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