Tunneling nanotubes, a novel mode of tumor cell-macrophage communication in tumor cell invasion.
作者： Samer J. Hanna , Kessler McCoy-Simandle , Edison Leung , Alessandro Genna , John Condeelis
DOI: 10.1242/JCS.223321
关键词:
摘要: The interaction between tumor cells and macrophages is crucial in promoting invasion metastasis. In this study, we examined a novel mechanism of intercellular communication, namely membranous actin-based tunneling nanotubes (TNTs), that occurs the promotion macrophage-dependent cell invasion. presence heterotypic TNTs induced invasive morphology, which was dependent on EGF-EGFR signaling. Furthermore, reduction protein involved TNT formation, M-Sec (TNFAIP2), inhibited elongation, blocked ability to invade 3D reduced long-distance streaming vitro Using an vivo zebrafish model recreates macrophage-mediated invasion, observed TNT-mediated distant metastatic foci areas spread. Overall, our studies support role for as means leads progression
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