Developmental and species-divergent globin switching are driven by BCL11A

作者: Vijay G. Sankaran , Jian Xu , Tobias Ragoczy , Gregory C. Ippolito , Carl R. Walkley

DOI: 10.1038/NATURE08243

关键词:

摘要: … Here we show that the human γ-globin (HBG) genes in these mice behave as murine embryonic globin genes, revealing a limitation of the model and demonstrating that critical …

参考文章(38)
Kathleen McGrath, James Palis, Ontogeny of erythropoiesis in the mammalian embryo. Current Topics in Developmental Biology. ,vol. 82, pp. 1- 22 ,(2008) , 10.1016/S0070-2153(07)00001-4
Susanna Porcu, Michael Kitamura, Ewa Witkowska, Zemin Zhang, Annick Mutero, Chin Lin, Judy Chang, Karin M.L. Gaensler, The Human β Globin Locus Introduced by YAC Transfer Exhibits a Specific and Reproducible Pattern of Developmental Regulation in Transgenic Mice Blood. ,vol. 90, pp. 4602- 4609 ,(1997) , 10.1182/BLOOD.V90.11.4602
Vijay G. Sankaran, Tobias F. Menne, Jian Xu, Thomas E. Akie, Guillaume Lettre, Ben Van Handel, Hanna K. A. Mikkola, Joel N. Hirschhorn, Alan B. Cantor, Stuart H. Orkin, Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor BCL11A Science. ,vol. 322, pp. 1839- 1842 ,(2008) , 10.1126/SCIENCE.1165409
M. D. Wilson, N. L. Barbosa-Morais, D. Schmidt, C. M. Conboy, L. Vanes, V. L. J. Tybulewicz, E. M. C. Fisher, S. Tavare, D. T. Odom, Species-specific transcription in mice carrying human chromosome 21. Science. ,vol. 322, pp. 434- 438 ,(2008) , 10.1126/SCIENCE.1160930
K M Gaensler, M Kitamura, Y W Kan, Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 11381- 11385 ,(1993) , 10.1073/PNAS.90.23.11381
Pentao Liu, Jonathan R Keller, Mariaestela Ortiz, Lino Tessarollo, Rivka A Rachel, Takuro Nakamura, Nancy A Jenkins, Neal G Copeland, Bcl11a is essential for normal lymphoid development Nature Immunology. ,vol. 4, pp. 525- 532 ,(2003) , 10.1038/NI925
B. S. Braun, D. A. Tuveson, N. Kong, D. T. Le, S. C. Kogan, J. Rozmus, M. M. Le Beau, T. E. Jacks, K. M. Shannon, Somatic activation of oncogenic Kras in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 597- 602 ,(2004) , 10.1073/PNAS.0307203101
T Papayannopoulou, A Torrealba de Ron, R Veith, G Knitter, G Stamatoyannopoulos, Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics Science. ,vol. 224, pp. 617- 619 ,(1984) , 10.1126/SCIENCE.6200940
C. Peschle, F. Mavilio, A. Carè, G. Migliaccio, A. R. Migliaccio, G. Salvo, P. Samoggia, S. Petti, R. Guerriero, M. Marinucci, D. Lazzaro, G. Russo, G. Mastroberardino, Haemoglobin switching in human embryos: asynchrony of ζ → α and ε → γ-globin switches in primitive and definitive erythropoietic lineage Nature. ,vol. 313, pp. 235- 238 ,(1985) , 10.1038/313235A0