Development of a conceptual model evaluating the humanistic and economic burden of Crohn’s disease: implications for patient-reported outcomes measurement and economic evaluation

摘要: The primary objective of this review is to develop a conceptual model for Crohn’s disease (CD) outlining the burden patients, healthcare systems and wider society, as reported in scientific literature. A search was conducted using MEDLINE, PsycINFO, EconLit, Health Economic Evaluation Database Centre Reviews Dissemination databases. Patient-reported outcome (PRO) measures widely used CD were reviewed according US FDA PRO Guidance Industry. resulting highlights characterization by gastrointestinal disturbances, extra-intestinal systemic symptoms. These symptoms impact physical functioning, ability complete daily activities, emotional wellbeing, social sexual functioning work. Gaps coverage evidence reliability validity some noted. Review findings also highlight substantial direct indirect costs associated with CD. Evidence from literature con...