Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase.
作者： Gillian M Nicholas , Lisa L Eckman , Satyajit Ray , Robert O Hughes , Jeffrey A Pfefferkorn
DOI: 10.1016/S0960-894X(02)00385-2
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摘要: Abstract A series of bromotyrosine-derived compounds, including marine natural products and members a psammaplin A-inspired combinatorial synthetic library, were screened for their ability to inhibit the Mycobacterium tuberculosis detoxification enzyme mycothiol- S -conjugate amidase (MCA). Correlations between structures respective IC 50 values (which range from 3 μM 2.7 mM) should prove valuable when optimizing more potent inhibitors MCA.
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