Immunologic influences of hyperthermia in a rat model of obstructive jaundice.
作者： Bahadir M. Gũllũoğlu , Ali Bekrak˙ı , Nilgũn Çer˙ıkç˙ıoğlu , Gũner Sõylet˙ır , A. Õzdemir Aktan
关键词:
摘要: In this study, the effect of hyperthermia on immune response and bacterial translocation from gut in jaundiced rats was assessed. hyperthermic (HP; N = 8) normothermic (NP; preconditioning groups, were preconditioned by for 15 min at 42°C or 38°C, respectively. After 8 hr, common bile duct (CBD) each animal ligated. thermal (TT; treatment groups (NT; CBD animals ligated, after seven days treated The (HP NP) killed day 7 (TT NT) hr they put a water bath. Determination immunophenotypes lymphocytes serum levels bilirubin done samples taken just death. quantity identify translocated bacteria determined tissue mesenteric lymph nodes, spleen, liver. NK cell expression as well CD4+/CD8+ ratio elevated HP group when compared to NP group. CD8+ found be low CD4+, CD11b+, B expressions not different between groups. All immunologic parameters similar TT NT other. group, half revealed translocation, whereas all other we only 1/8 rats. application rather than applying it establishment jaundice seemed beneficial. Hyperthermic led an improvement responses latter resulted increase with no favorable influence system. Bacterial unrelated status.
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sci-hub.se 参考文章(19)
K. C. Kregel, P. T. Wall, C. V. Gisolfi, Peripheral vascular responses to hyperthermia in the rat. Journal of Applied Physiology. ,vol. 64, pp. 2582- 2588 ,(1988) , 10.1152/JAPPL.1988.64.6.2582
Ronald L. E. Thompson, Shahin Ranjbar, Brian J. Rowlands, T-lymphocyte transformation in experimental obstructive jaundice: the role of serum-suppressive factors. World Journal of Surgery. ,vol. 17, pp. 783- 785 ,(1993) , 10.1007/BF01659096
WDB Clements, M McCaigue, P Erwin, I Halliday, BJ Rowlands, 5. Biliary decompression promotes Kupffer cell recovery in obstructive jaundice American Journal of Surgery. ,vol. 167, pp. 445- ,(1994) , 10.1016/0002-9610(94)90137-6
JESUS VILLAR, SERGIO P. RIBEIRO, J. BRENDAN M. MULLEN, MACIEK KULISZEWSKI, MARTIN POST, ARTHUR S. SLUTSKY, JOHN PIOVESAN, Induction of the heat shock response reduces mortality rate and organ damage in a sepsis-induced acute lung injury model Critical Care Medicine. ,vol. 22, pp. 914- 921 ,(1994) , 10.1097/00003246-199406000-00007
ES Ozveri, A Bekraki, A Cingi, M Yuksel, EE Demiralp, BC Yegen, AO Aktan, None, The effect of hyperthermic preconditioning on the immune system in rat peritonitis. Intensive Care Medicine. ,vol. 25, pp. 1155- 1159 ,(1999) , 10.1007/S001340051028
J. A. Kennedy, R. W. Parks, W. D. B. Clements, B. J. Rowlands, J. V. Reynolds, W. A. Tanner, Failure of macrophage activation in experimental obstructive jaundice: Association with bacterial translocation British Journal of Surgery. ,vol. 82, pp. 1433- 1434 ,(2005) , 10.1002/BJS.1800821046
S. M. Megison, C. W. Dunn, J. W. Horton, H. Chao, Effects of relief of biliary obstruction on mononuclear phagocyte system function and cell mediated immunity British Journal of Surgery. ,vol. 78, pp. 568- 571 ,(2005) , 10.1002/BJS.1800780516
Marja Jäättelä, Kalle Saksela, Eero Saksela, Heat shock protects WEHI‐164 target cells from the cytolysis by tumor necrosis factors α and β European Journal of Immunology. ,vol. 19, pp. 1413- 1417 ,(1989) , 10.1002/EJI.1830190810
M. C. Regan, R. M. Keane, D. Little, D. Bouchier-Hayes, Postoperative immunological function and jaundice. British Journal of Surgery. ,vol. 81, pp. 271- 273 ,(2005) , 10.1002/BJS.1800810239
R. L. E. Thompson, M. Hoper, T. Diamond, B. J. Rowlands, Development and reversibility of T lymphocyte dysfunction in experimental obstructive jaundice. British Journal of Surgery. ,vol. 77, pp. 1229- 1232 ,(2005) , 10.1002/BJS.1800771112