Failure of macrophage activation in experimental obstructive jaundice: Association with bacterial translocation
作者： J. A. Kennedy , R. W. Parks , W. D. B. Clements , B. J. Rowlands , J. V. Reynolds
关键词:
摘要: Bacterial translocation from the gastrointestinal tract and macrophage activation are central to current theories of sepsis. The relevance both in obstructive jaundice is unclear. effect bile duct ligation for 7 days on bacterial mesenteric lymph nodes a rat model was examined. Compared with an incidence zero sham-ligated controls, bile-duct ligated rats had 67 per cent Gram-negative colonization nodes. This associated significant (P < 0.001) decrease tumour necrosis factor, superoxide anion nitric oxide production compared that sham controls. Spontaneous occurs experimental marked suppression activation. suggests mechanism whereby jaundiced patients may be more susceptible persistent infection but relatively protected against uncontrolled
sci-hub.se 参考文章(50)
Sittig Km, Deitch Ea, Specian Rd, Slocum Mm, Absence of intestinal bile promotes bacterial translocation. American Surgeon. ,vol. 58, pp. 305- 310 ,(1992)
Dennis J Stuehr, C. F. Nathan, A. H. Ding, Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. Journal of Immunology. ,vol. 141, pp. 2407- 2412 ,(1988)
J.W. Greve, D.J. Gouma, P.B. Soeters, W.A. Buurman, Suppression of cellular immunity in obstructive jaundice is caused by endotoxins: A study with germ-free rats Gastroenterology. ,vol. 98, pp. 478- 485 ,(1990) , 10.1016/0016-5085(90)90841-N
F P Heinzel, The role of IFN-gamma in the pathology of experimental endotoxemia. Journal of Immunology. ,vol. 145, pp. 2920- 2924 ,(1990)
Allan I. Jacob, Philip K. Goldberg, Norman Bloom, George A. Degenshein, Philip J. Kozinn, Endotoxin and Bacteria in Portal Blood Gastroenterology. ,vol. 72, pp. 1268- 1270 ,(1977) , 10.1016/S0016-5085(77)80025-5
E S Fox, P Thomas, S A Broitman, Comparative studies of endotoxin uptake by isolated rat Kupffer and peritoneal cells. Infection and Immunity. ,vol. 55, pp. 2962- 2966 ,(1987) , 10.1128/IAI.55.12.2962-2966.1987
Rodney D. Berg, Alva W. Garlington, Translocation of Certain Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Nodes and Other Organs in a Gnotobiotic Mouse Model Infection and Immunity. ,vol. 23, pp. 403- 411 ,(1979) , 10.1128/IAI.23.2.403-411.1979
Terje Espevik, Jon Nissen-Meyer, A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes. Journal of Immunological Methods. ,vol. 95, pp. 99- 105 ,(1986) , 10.1016/0022-1759(86)90322-4
Carol E.H. Scott-Conner, James B. Grogan, Kenneth S. Scher, Jack Bernstein, Impaired clearance of Escherichia coli bacteremia in early biliary obstruction. American Journal of Surgery. ,vol. 157, pp. 210- 214 ,(1989) , 10.1016/0002-9610(89)90530-8
HENRY A. PITT, ANTOINETTE S. GOMES, JUAN F. LOIS, LINDA L. MANN, LARRY S. DEUTSCH, WILLIAM P. LONGMIRE, Does preoperative percutaneous biliary drainage reduce operative risk or increase hospital cost Annals of Surgery. ,vol. 201, pp. 545- 553 ,(1985) , 10.1097/00000658-198505000-00002