CEACAM1: Una molécula multifuncional
作者： Benibelks Albarrán Somoza , Adrián Daneri Navarro
DOI:
关键词:
摘要: Lamolecula de adhesion celular antigeno carcinoembrionario 1 (CEACAM1), es una glicoproteina perteneciente a la superfamilia las inmunoglobulinas, encontrada sobre superficie gran variedad epitelios y celulas del sistema hematopoyetico humanos otras especies. Interviene en diversos procesos biologicos como: celular, reconocimiento bacterias virus, regulacion eventos celulares, entre otros. Recientemente se le ha atribuido un papel importante inhibicion crecimiento tumoral algunas funciones inmunologico. La disminucion expresion CEACAM1 tumores origen epitelial (carcinoma colorectal, adenocarcinoma pulmon, carcinoma ovario endometrial) indica que estamolecula puede tener supresion tumoral. Sin embargo, observado incremento gastrico escamosas pulmon. De ahi CEACAM1, podria ser utilizado como nuevo marcador para diagnostico, monitoreo pronostico algunos carcinomas.
ula.ve 参考文章(20)
Ana M. Texieira, Atul K. Bhan, Atsushi Mizoguchi, Richard S. Blumberg, Emiko Mizoguchi, Gordon J. Freeman, Gary J. Russell, Victor M. Morales, Nalan Utku, Sara E. Russell, Kevin W. Johnson, Andreas Christ, Suzanne M. Watt, Hyun S. Kim, Regulation of human intestinal intraepithelial lymphocyte cytolytic function by biliary glycoprotein (CD66a) Journal of Immunology. ,vol. 163, pp. 1363- 1370 ,(1999)
Atsushi Nakajima, Hideki Iijima, Markus F. Neurath, Takashi Nagaishi, Edward E. S. Nieuwenhuis, Raktima Raychowdhury, Jonathan Glickman, Dianna M. Blau, Sara Russell, Kathryn V. Holmes, Richard S. Blumberg, Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. Journal of Immunology. ,vol. 168, pp. 1028- 1035 ,(2002) , 10.4049/JIMMUNOL.168.3.1028
Robert Kammerer, Detlef Stober, Bernhard B. Singer, Björn Öbrink, Jörg Reimann, Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation The Journal of Immunology. ,vol. 166, pp. 6537- 6544 ,(2001) , 10.4049/JIMMUNOL.166.11.6537
Silvia Bolland, Wolfgang Zimmermann, Tie Chen, Akito Maeda, Ines Chen, James Parker, Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signals Journal of Leukocyte Biology. ,vol. 70, pp. 335- 340 ,(2001) , 10.1189/JLB.70.2.335
Christer Busch, Tor Arne Hanssen, Christoph Wagener, Björn Öbrink, Down-regulation of CEACAM1 in human prostate cancer: Correlation with loss of cell polarity, increased proliferation rate, and Gleason grade 3 to 4 transition Human Pathology. ,vol. 33, pp. 290- 298 ,(2002) , 10.1053/HUPA.2002.32218
Sten Hammarström, The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues. Seminars in Cancer Biology. ,vol. 9, pp. 67- 81 ,(1999) , 10.1006/SCBI.1998.0119
Eckart Laack, Haleh Nikbakht, Anja Peters, Christian Kugler, Yvonne Jasiewicz, Lutz Edler, Jens Brümmer, Udo Schumacher, Dieter Kurt Hossfeld, Expression of CEACAM1 in Adenocarcinoma of the Lung: A Factor of Independent Prognostic Significance Journal of Clinical Oncology. ,vol. 20, pp. 4279- 4284 ,(2002) , 10.1200/JCO.2002.08.067
Maria Huber, Luisa Izzi, Philippe Grondin, Caroline Houde, Tilo Kunath, André Veillette, Nicole Beauchemin, The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. Journal of Biological Chemistry. ,vol. 274, pp. 335- 344 ,(1999) , 10.1074/JBC.274.1.335
Gediminas Greicius, Eva Severinson, Nicole Beauchemin, Björn Öbrink, Bernhard B. Singer, CEACAM1 is a potent regulator of B cell receptor complex‐induced activation Journal of Leukocyte Biology. ,vol. 74, pp. 126- 134 ,(2003) , 10.1189/JLB.1202594
Fritz Grunert, Christoph Rochlitz, Luigi Terracciano, Peter Jantscheff, Gennaro De Libero, Alena Donda, Lucia Mori, Abdijapar Shamshiev, Ilaria Carena, Christian Mottet, Markus H. Heim, Christoph Beglinger, Locally inducible CD66a (CEACAM1) as an amplifier of the human intestinal T cell response. European Journal of Immunology. ,vol. 30, pp. 2593- 2603 ,(2000) , 10.1002/1521-4141(200009)30:9<2593::AID-IMMU2593>3.0.CO;2-0