Role of TGF-β in Osteolytic Bone Metastases
作者： Laurent Bartholin , Theresa Guise
DOI: 10.1007/978-1-59745-293-9_7
关键词:
摘要: Transforming growth factor-β (TGF-β) is one of the most abundant factors stored in mineralized bone matrix. Accumulating evidences indicate that TGF-β promotes invasion and metastasis transformed cancer cell has a distinct role to promote through its effects stimulate tumor production disrupt normal remodeling. In this chapter, we present data describing osteolytic metastases from breast cancer. very complex during different steps metastasis, opening new therapeutic opportunities for treatment metastases.
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Wim Van Hul, Katrien Janssens, Sophie Janssens, Peter ten Dijke, Transforming Growth Factor- 1 to the Bone ,(2005)
Theresa A. Guise, Khalid S. Mohammad, Endothelins in bone cancer metastases. Cancer treatment and research. ,vol. 118, pp. 197- 212 ,(2004) , 10.1007/978-1-4419-9129-4_9
Andrea M. Mastro, Carol V. Gay, Danny R. Welch, The skeleton as a unique environment for breast cancer cells Clinical & Experimental Metastasis. ,vol. 20, pp. 275- 284 ,(2003) , 10.1023/A:1022995403081
R. Wieser, J.L. Wrana, J. Massagué, GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. The EMBO Journal. ,vol. 14, pp. 2199- 2208 ,(1995) , 10.1002/J.1460-2075.1995.TB07214.X
Takeshi Kiriyama, Matthew T. Gillespie, Jane A. Glatz, Seiji Fukumoto, jane M. Moseley, T.John Martin, Transforming growth factor β stimulation of parathyroid hormone-related protein (PTHrP): a paracrine regulator?: Molecular and cellular endocrinology, 92 (1993) 55–62 Molecular and Cellular Endocrinology. ,vol. 94, pp. 1- 5 ,(1993) , 10.1016/0303-7207(93)90062-O
Darryl Carter, Taiping Chen, Michael Reiss, Laure Garrigue-Antar, Transforming Growth Factor β Type I Receptor Kinase Mutant Associated with Metastatic Breast Cancer Cancer Research. ,vol. 58, pp. 4805- 4810 ,(1998)
M.P. Roudier, H. Vesselle, L.D. True, C.S. Higano, S.M. Ott, S.H. King, R.L. Vessella, Bone histology at autopsy and matched bone scintigraphy findings in patients with hormone refractory prostate cancer: The effect of bisphosphonate therapy on bone scintigraphy results Clinical & Experimental Metastasis. ,vol. 20, pp. 171- 180 ,(2003) , 10.1023/A:1022627421000
Young-Yun Kong, Hiroki Yoshida, Ildiko Sarosi, Hong-Lin Tan, Emma Timms, Casey Capparelli, Sean Morony, Antonio J. Oliveira-dos-Santos, Gwyneth Van, Annick Itie, Wilson Khoo, Andrew Wakeham, Colin R. Dunstan, David L. Lacey, Tak W. Mak, William J. Boyle, Josef M. Penninger, OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis Nature. ,vol. 397, pp. 315- 323 ,(1999) , 10.1038/16852
Lalage M. Wakefield, Binwu Tang, Anita B. Roberts, Anita B. Roberts, W. Tony Parks, W. Tony Parks, Stephen Yoo, Fang Tian, Stacey Da Costa Byfield, Angelina Felici, Ester Piek, Ester Piek, Reduction in Smad2/3 Signaling Enhances Tumorigenesis but Suppresses Metastasis of Breast Cancer Cell Lines Cancer Research. ,vol. 63, pp. 8284- 8292 ,(2003)
Donna M. Peehl, Zijie Sun, Manju Sharma, Fajun Yang, Steven A. Hayes, Mark Zarnegar, Peter ten Dijke, SMAD3 Represses Androgen Receptor-mediated Transcription Cancer Research. ,vol. 61, pp. 2112- 2118 ,(2001)